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Both adult and adolescent patients who respond acutely should generally be maintained on their effective dose beyond the acute episode.
Efficacy was established in 3 short-term trials in children and adolescents (ages 5 to 17 years) can be administered once or twice daily. May increase the dose at intervals of 24 hours or greater, in increments of 1 to 2 mg per day, as tolerated, to a recommended dose of 4 to 8 mg per day.
Patients experiencing persistent somnolence may benefit from administering half the daily dose twice daily. While it is generally agreed that pharmacological treatment beyond an acute response in mania is desirable, both for maintenance of the initial response and for prevention of new manic episodes, there are no systematically obtained data to support the use of Risperdal can be administered once daily, or half the total daily dose can be administered twice daily.
For patients with body weight less than 20 kg, initiate dosing at 0.25 mg per day.
Viral, bacterial, or parasitic coinfection may confound the clinical manifestations.
Prevention is largely based on mass treatment of school children, with variable achievements in different countries.